![]() Reduction of cortical temperature to reduce spiking ĭependent on temperature conduction through tissue Irreversible removal of neural tissue ĭependent on how completely the target brain area is removed ĭegeneration of upstream areas (e.g., thalamus) Īctivation of inhibitory neurons via reagents Īrea of effect relies on diffusion of reagent which may vary between reagents (e.g., muscimol spreads maximally and γ-aminobutyric acid minimally) ĭifficult to apply to certain brain areas However, recent advances in available inactivation methods offer increasingly more spatially and temporally precise manipulations ( Table 1). While electrophysiological recordings indicate the involvement of AC in nearly all auditory behaviours, from representing basic acoustic properties to associative learning, the results of silencing studies vary greatly. Later on, most investigations of AC function became centred on recording cortical activity associated with specific stimuli and behaviours, shifting the focus to correlational studies of neuronal activity and sensory stimuli. Initially, the leading method of studying its function was through lesioning different areas of AC in animal models and observing the resulting impairments, with the aim of identifying behaviours for which AC is necessary. Since the location of auditory cortex (AC) in the primate brain was first characterised in 1875, researchers have been attempting to understand its role in auditory behaviours. ![]() Challenges in defining auditory cortex function ![]()
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